Human Retrovirus and Multiple Sclerosis
نویسندگان
چکیده
منابع مشابه
Analysis of Human Endogenous Retrovirus Expression in Multiple Sclerosis Plaques
BACKGROUND It has been suggested that Human endogenous retroviruses (HERVs) are associated with multiple sclerosis (MS) pathogenesis. The objective of this study was to broadly evaluate the expression of HERV core (GAG) and envelope (ENV) genes in diseased brain white matter samples from MS patients compared to normal controls. METHODS Twenty-eight HERV GAG and 88 ENV gene sequences were retr...
متن کاملMultiple sclerosis-associated retrovirus and MS prognosis: an observational study.
MS-associated retrovirus (MSRV) in the CSF may have gliotoxic properties and could be associated with a more disabling MS. The authors tested this hypothesis in 15 untreated patients with MS: 6 MSRV- and 9 MSRV+ at the time of CSF withdrawal. After a 3-year mean follow-up, MSRV- patients showed a stable MS course, whereas MSRV+ patients had a progressive course (p = 0.01).
متن کاملMultiple sclerosis-associated retrovirus (MSRV) in Sardinian MS patients.
Blood and CSF of Sardinian patients with MS and neurologic control subjects were tested for MS-associated retrovirus (MSRV). CSF detection in MS was 50% at clinical onset, increasing with temporal disease progression, and 40% in control subjects. In blood, MSRV was detected in all MS patients, in most patients with inflammatory neurologic diseases, and rarely in healthy blood donors. MSRV may r...
متن کاملHuman Endogenous Retrovirus HERV-Fc1 Association with Multiple Sclerosis Susceptibility: A Meta-Analysis
BACKGROUND Human endogenous retroviruses (HERVs) are repetitive sequences derived from ancestral germ-line infections by exogenous retroviruses and different HERV families have been integrated in the genome. HERV-Fc1 in chromosome X has been previously associated with multiple sclerosis (MS) in Northern European populations. Additionally, HERV-Fc1 RNA levels of expression have been found increa...
متن کاملExpression of HERV-Fc1, a human endogenous retrovirus, is increased in patients with active multiple sclerosis.
Multiple sclerosis (MS) is considered to be an autoimmune disease with an unknown cause and with immune system dysregulation. Among environmental factors, viruses are most often connected with the etiology of MS. Human endogenous retroviruses (HERVs) constitute 5 to 8% of human genomic DNA and have been detected as transcripts and proteins in the central nervous system (CNS) and peripheral bloo...
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ژورنال
عنوان ژورنال: Mayo Clinic Proceedings
سال: 1991
ISSN: 0025-6196
DOI: 10.1016/s0025-6196(12)62089-8